(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

Base Information

Chemical Name:(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt
CAS No.:91841-42-8
Molecular Formula:C₁₃H₂₄N₂*C₁₈H₂₈N₂O₇SSi
Molecular Weight:652.928
Hs Code.:

(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

Synonyms:(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

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Chemical Property of (3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

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Technology Process of (3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

There total 6 articles about (3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 87633-94-1
3,3,6,9,9-pentamethyl-10-sulfo-2,10-diazabicyclo<4.4.0>-1-decene

: 91841-40-6
(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-azetidinone

: 91841-42-8
(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

Guidance literature:: In tetrahydrofuran; 1,4-dioxane; at 50 - 55 ℃; for 1.5h;
DOI:10.1248/cpb.32.1303

Reference yield:

: 91814-60-7
(4R)-1-tert-butyldimethylsilyl-3-tert-butyldimethylsilyloxymethyl-2-azetidinone

: 91841-42-8
(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

Guidance literature:: Multi-step reaction with 5 steps

2: H₂ / 10 percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature

3: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 2 h / Ambient temperature

4: 99 percent / 1) potassium fluoride; 2) acetic acid / methanol / 15 h / 0 °C

5: 99 percent / tetrahydrofuran; dioxane / 1.5 h / 50 - 55 °C

With potassium fluoride; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1248/cpb.32.1303

Reference yield:

: 91841-31-5
(3S,4R)-3-azido-1-tert-butyldimethylsilyl-4-tert-butyldimethylsilyloxymethyl-2-azetidinone

: 91841-42-8
(3S,4R)-4-tert-bytyldimethylsilyloxymethyl-3-phenoxyacetamido-2-oxo-1-sulfoazetidinone 3,3,6,9,9-pentamethyl-2,10-diazabicyclo<4.4.0>-1-decene salt

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / 10 percent Pd-C / tetrahydrofuran / 1.5 h / Ambient temperature

2: N,N'-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole / tetrahydrofuran / 2 h / Ambient temperature

3: 99 percent / 1) potassium fluoride; 2) acetic acid / methanol / 15 h / 0 °C

4: 99 percent / tetrahydrofuran; dioxane / 1.5 h / 50 - 55 °C

With potassium fluoride; hydrogen; benzotriazol-1-ol; acetic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1248/cpb.32.1303