3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

Base Information

Chemical Name:3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol
CAS No.:841259-42-5
Molecular Formula:C₂₈H₂₇BrN₂O₅
Molecular Weight:551.437
Hs Code.:

Synonyms:3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

Suppliers and Price of 3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

There total 6 articles about 3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 3378-82-3
1-bromo-2-naphthaldehyde

: 841259-40-3
3-benzyloxy-4-iodo-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

: 841259-42-5
3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

Guidance literature:: 3-benzyloxy-4-iodo-5-(1-methoxycarbonyl-4-piperidyl)isoxazol; With isopropylmagnesium chloride; In tetrahydrofuran; hexane; at -30 - 0 ℃; for 1h;

1-bromo-2-naphthaldehyde; In tetrahydrofuran; hexane; at 20 ℃; for 25h;
DOI:10.1021/jm049256w

Reference yield:

: 37763-43-2
1-bromo-2-(bromomethyl)naphthalene

: 841259-42-5
3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2-nitropropane; NaOEt / ethanol / 65 h / 20 °C

2.1: iPrMgCl / tetrahydrofuran; hexane / 1 h / -30 - 0 °C

2.2: 72 percent / tetrahydrofuran; hexane / 25 h / 20 °C

With 2-nitropropane; isopropylmagnesium chloride; sodium ethanolate; In tetrahydrofuran; ethanol; hexane;
DOI:10.1021/jm049256w

Reference yield:

: 2586-62-1
1-bromo-2-methylnaphtalene

: 841259-42-5
3-benzyloxy-4-[(1-bromo-2-naphthyl)hydroxymethyl]-5-(1-methoxycarbonyl-4-piperidyl)isoxazol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-bromosuccinimide; benzoyl peroxide / CCl₄ / 40 h / 75 °C

2.1: 2-nitropropane; NaOEt / ethanol / 65 h / 20 °C

3.1: iPrMgCl / tetrahydrofuran; hexane / 1 h / -30 - 0 °C

3.2: 72 percent / tetrahydrofuran; hexane / 25 h / 20 °C

With N-Bromosuccinimide; 2-nitropropane; isopropylmagnesium chloride; sodium ethanolate; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; hexane;
DOI:10.1021/jm049256w