(S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate

Base Information

Chemical Name:(S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate
CAS No.:1187646-48-5
Molecular Formula:C₃₂H₂₆Cl₂N₈O₄
Molecular Weight:657.516
Hs Code.:

Synonyms:(S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate

Suppliers and Price of (S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate

There total 3 articles about (S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 942316-73-6
(2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-prop-2-enoic acid

: 1187648-40-3
(S)-2-(4-(6-(1-amino-2-phenylethyl)-3-chloropyridazin-4-yl)phenylamino)-2-oxoethyl acetate

: 1187646-48-5
(S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate

Guidance literature:: (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-prop-2-enoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In tetrahydrofuran; for 0.166667h;

(S)-2-(4-(6-(1-amino-2-phenylethyl)-3-chloropyridazin-4-yl)phenylamino)-2-oxoethyl acetate; In tetrahydrofuran; for 0.166667h;

Reference yield:

: 879016-22-5
5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)benzaldehyde

: 1187646-48-5
(S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0 - 20 °C

1.2: 0.5 h

2.1: methanol; sodium hydroxide / 2.5 h / 20 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 0.17 h

3.2: 0.17 h

With methanol; sodium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran; 1.1: Horner-Emmons Condensation / 1.2: Horner-Emmons Condensation;

Reference yield:

: 942316-72-5
methyl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

: 1187646-48-5
(S,E)-2-(4-(3-chloro-6-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-4-yl)phenylamino)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: methanol; sodium hydroxide / 2.5 h / 20 °C

2.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / tetrahydrofuran / 0.17 h

2.2: 0.17 h

With methanol; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; sodium hydroxide; In tetrahydrofuran;