(S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:(S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:157239-62-8
Molecular Formula:C₂₆H₂₇N₃O₂
Molecular Weight:413.519
Hs Code.:

Synonyms:(S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

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Technology Process of (S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 7 articles about (S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 294196-11-5
(S)-1-[4-(2-methylbenzoylamino)benzoyl]-5-(N-methyl-tert-butoxycarbonylamino)-2,3,4,5-tetrahydro-1H-1-benzazepine

: 157239-62-8
(S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(00)00388-4

Reference yield:

: 108166-22-9
4-[(2-Methylbenzoyl)amino]benzoic acid

: 157239-62-8
(S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / dimethylformamide; CH₂Cl₂ / 1 h / Heating

2: 1.35 g / pyridine / CH₂Cl₂; dimethylformamide / 2 h / 0 - 10 °C

3: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With pyridine; thionyl chloride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Chlorination / 2: Acylation / 3: Hydrolysis;
DOI:10.1016/S0040-4020(00)00388-4

Reference yield:

: 168080-31-7
4-(2-methylbenzoylamino)benzoic acid chloride

: 157239-62-8
(S)-5-methylamino-1-[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.35 g / pyridine / CH₂Cl₂; dimethylformamide / 2 h / 0 - 10 °C

2: 84 percent / trifluoroacetic acid / CH₂Cl₂ / 1 h / 20 °C

With pyridine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: Hydrolysis;
DOI:10.1016/S0040-4020(00)00388-4