1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one

Base Information

Chemical Name:1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one
CAS No.:1448437-84-0
Molecular Formula:C₂₁H₂₈N₄O₃
Molecular Weight:384.478
Hs Code.:

Synonyms:1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one

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Chemical Property of 1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one

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Technology Process of 1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one

There total 11 articles about 1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 3240-94-6
N-(2-chlorethyl)morpholine

: 1-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one

: 1448437-84-0
1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one

Guidance literature:: 1-(4-methoxybenzyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one; With sodium hydride; In N,N-dimethyl-formamide; for 0.166667h; Inert atmosphere;

N-(2-chlorethyl)morpholine; In N,N-dimethyl-formamide; at 20 - 90 ℃;

Reference yield:

: 1105039-59-5
N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

: 1448437-84-0
1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / water; tetrahydrofuran / 1.67 h / -78 - -40 °C / Inert atmosphere

1.2: 2 h / -78 °C

2.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; palladium diacetate / 1,4-dioxane / 8 h / 110 °C / Inert atmosphere

3.1: sodium hydride / water; tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 20 °C

4.1: water; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

5.1: Grubbs catalyst first generation / 1,2-dichloro-ethane / 5 h / 20 °C / Reflux; Inert atmosphere

6.1: acetic acid; palladium(II) hydroxide; hydrogen / ethanol / 6 h / 20 °C / Inert atmosphere

7.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

7.2: 20 - 90 °C

With Grubbs catalyst first generation; hydrogen; palladium diacetate; palladium(II) hydroxide; sodium hydride; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 2.1: |Buchwald-Hartwig Coupling;

Reference yield:

: 1448437-66-8
5-bromo-N-methoxy-1-(4-methoxybenzyl)-N-methyl-1H-pyrazole-4-carboxamide

: 1448437-84-0
1-(4-methoxybenzyl)-8-(2-morpholino ethyl)-5,6,7,8-tetrahydropyrazolo[3,4-b]azepin-4(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate; palladium diacetate / 1,4-dioxane / 8 h / 110 °C / Inert atmosphere

2.1: sodium hydride / water; tetrahydrofuran; N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 20 °C

3.1: water; tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

4.1: Grubbs catalyst first generation / 1,2-dichloro-ethane / 5 h / 20 °C / Reflux; Inert atmosphere

5.1: acetic acid; palladium(II) hydroxide; hydrogen / ethanol / 6 h / 20 °C / Inert atmosphere

6.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / Inert atmosphere

6.2: 20 - 90 °C

With Grubbs catalyst first generation; hydrogen; palladium diacetate; palladium(II) hydroxide; sodium hydride; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In tetrahydrofuran; 1,4-dioxane; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 1.1: |Buchwald-Hartwig Coupling;