tert-butyl (5R)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylate

Base Information

Chemical Name:tert-butyl (5R)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylate
CAS No.:731807-68-4
Molecular Formula:C₁₂H₁₉NO₅
Molecular Weight:257.287
Hs Code.:

Synonyms:(5R,8RS)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl (5R)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylate

Chemical Property:

Vapor Pressure:1.74E-09mmHg at 25°C

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of tert-butyl (5R)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylate

There total 4 articles about tert-butyl (5R)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 144085-23-4
N-tert-butoxycarbonyl-L-α-allylproline

: 731807-68-4
(5R,8RS)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium periodate; osmium(VIII) oxide; In methanol; tert-butyl alcohol; at 20 ℃; for 2h;
DOI:10.1016/j.tet.2004.04.052

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 731807-68-4
(5R,8RS)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 71 percent / CH₂Cl₂ / 72 h / 20 °C

2.1: 81 percent / aq. NaOH / methanol / 1 h / Heating

3.1: O₃ / CH₂Cl₂ / 0.32 h / -78 °C

3.2: 75 percent / PPh₃ / CH₂Cl₂ / 2.5 h / 20 °C

With sodium hydroxide; ozone; In methanol; dichloromethane;
DOI:10.1021/jm049644y

Reference yield:

: 112348-45-5
(R)-N-(tert-butoxycarbonyl)-2-allylproline methyl ester

: 731807-68-4
(5R,8RS)-8-hydroxy-6-oxo-7-oxa-1-azaspiro[4.4]nonane-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 81 percent / aq. NaOH / methanol / 1 h / Heating

2.1: O₃ / CH₂Cl₂ / 0.32 h / -78 °C

2.2: 75 percent / PPh₃ / CH₂Cl₂ / 2.5 h / 20 °C

With sodium hydroxide; ozone; In methanol; dichloromethane;
DOI:10.1021/jm049644y