((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate

Base Information

Chemical Name:((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate
CAS No.:1421054-19-4
Molecular Formula:C₂₅H₃₃NO₅S
Molecular Weight:459.607
Hs Code.:

Synonyms:((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate

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Chemical Property of ((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate

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Technology Process of ((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate

There total 3 articles about ((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: C₁₃H₁₈O₄S

: 100-47-0
benzonitrile

: 590-86-3
isovaleraldehyde

: 1421054-19-4
((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate

Guidance literature:: With boron trifluoride diethyl etherate; at 0 - 25 ℃; stereoselective reaction;
DOI:10.1021/ol303364j

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1421054-19-4
((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; di(n-butyl)tin oxide / dichloromethane / 0.83 h / 25 °C

2: boron trifluoride diethyl etherate / 0 - 25 °C

With boron trifluoride diethyl etherate; di(n-butyl)tin oxide; triethylamine; In dichloromethane; 2: |Ritter Amidation;
DOI:10.1021/ol303364j

Reference yield:

: 955044-11-8
C₆H₁₂O₂

: 1421054-19-4
((2S,4S,5R,6S)-4-(benzamido)-tetrahydro-6-isobutyl-5-methyl-2H-pyran-2-yl)methyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; di(n-butyl)tin oxide / dichloromethane / 0.83 h / 25 °C

2: boron trifluoride diethyl etherate / 0 - 25 °C

With boron trifluoride diethyl etherate; di(n-butyl)tin oxide; triethylamine; In dichloromethane; 2: |Ritter Amidation;
DOI:10.1021/ol303364j