N-Cbz-2-piperidinecarboxylic acid T-butyl ester

Base Information

Chemical Name:N-Cbz-2-piperidinecarboxylic acid T-butyl ester
CAS No.:71170-89-3
Molecular Formula:C18H25 N O4
Molecular Weight:319.4
Hs Code.:2933399090
DSSTox Substance ID:DTXSID60391608
Nikkaji Number:J1.218.462J
Mol file:71170-89-3.mol

Synonyms:71170-89-3;N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER;1-benzyl 2-tert-butyl piperidine-1,2-dicarboxylate;1-O-benzyl 2-O-tert-butyl piperidine-1,2-dicarboxylate;1-benzyl 2-(tert-butyl) piperidine-1,2-dicarboxylate;DTXSID60391608;WCA17089;AKOS015911223;CS-W001624;s12100;AS-67454;FT-0654560;A837104;Piperidine-1,2-dicarboxylic acid 1-benzyl 2-tert-butyl ester

Suppliers and Price of N-Cbz-2-piperidinecarboxylic acid T-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
1-Benzyl2-tert-butylpiperidine-1,2-dicarboxylate 97%
1g
$ 202.00

American Custom Chemicals Corporation
N-CBZ-2-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER 95.00%
5G
$ 909.56

Alichem
N-Cbz-2-piperidinecarboxylicacidt-butylester
1g
$ 1651.30

Alichem
N-Cbz-2-piperidinecarboxylicacidt-butylester
500mg
$ 1068.20

Activate Scientific
N-Cbz-2-Piperidinecarboxylicacidt-butylester 95+%
5 g
$ 502.00

Total 7 raw suppliers

Chemical Property of N-Cbz-2-piperidinecarboxylic acid T-butyl ester

Chemical Property:

PSA：55.84000
LogP:3.45730
XLogP3:3.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:319.17835828
Heavy Atom Count:23
Complexity:410

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Benzyl2-tert-butylpiperidine-1,2-dicarboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C1CCCCN1C(=O)OCC2=CC=CC=C2

Technology Process of N-Cbz-2-piperidinecarboxylic acid T-butyl ester

There total 5 articles about N-Cbz-2-piperidinecarboxylic acid T-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 28697-07-6
N-benzyloxycarbonyl D/L-pipecolinic acid

: 115-11-7,15220-85-6
isobutene

: 71170-89-3
N-(benzyloxycarbonyl)-DL-pipecolinic acid tert-butyl ester

Guidance literature:: With sulfuric acid; In diethyl ether; for 24h; Ambient temperature;
DOI:10.1021/jo00056a018

Reference yield:

: 4043-87-2,83680-83-5
pipecolic Acid

: 71170-89-3
N-(benzyloxycarbonyl)-DL-pipecolinic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 2 N NaOH / 1 h / < 5 deg C to room temperature

2: 58 percent / H₂SO₄ / diethyl ether / 24 h / Ambient temperature

With sodium hydroxide; sulfuric acid; In diethyl ether;
DOI:10.1021/jo00056a018

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 71170-89-3
N-(benzyloxycarbonyl)-DL-pipecolinic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 2 N NaOH / 1 h / < 5 deg C to room temperature

2: 58 percent / H₂SO₄ / diethyl ether / 24 h / Ambient temperature

With sodium hydroxide; sulfuric acid; In diethyl ether;
DOI:10.1021/jo00056a018