tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

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Chemical Name:tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate
CAS No.:1615249-71-2
Molecular Formula:C₂₄H₃₅N₃O₅
Molecular Weight:445.559
Hs Code.:

Synonyms:tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

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Chemical Property of tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

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Technology Process of tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

There total 5 articles about tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 879275-33-9
(R)-1-piperidin-3-ylmethyl-carbamic acid tert-butyl ester

: (S)-1-(4-Methoxy-benzyl)-5-oxo-pyrrolidine-2-carbonyl chloride

: 1615249-71-2
tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

Guidance literature:: (R)-1-piperidin-3-ylmethyl-carbamic acid tert-butyl ester; With triethylamine; In dichloromethane; at 0 ℃; for 0.166667h;

(S)-1-(4-Methoxy-benzyl)-5-oxo-pyrrolidine-2-carbonyl chloride; In dichloromethane; at 0 - 20 ℃; for 3h;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 87341-48-8
(S)-(+)-N-p-methoxybenzyl-5-oxoproline

: 1615249-71-2
tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / dichloromethane / 12 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 3 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 1615249-71-2
tert-butyl ((S)-1-((S)-1-(4-methoxybenzyl)-5-oxopyrrolidine-2-carbonyl)piperidin-3-yl)methylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -20 °C / Inert atmosphere

1.2: 4 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; water / methanol / 5 h / 0 - 20 °C

3.1: oxalyl dichloride / dichloromethane / 12 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0.17 h / 0 °C

4.2: 3 h / 0 - 20 °C

With oxalyl dichloride; water; sodium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2014.05.017