4-(Trifluoroacetyl)-diphenyl ether

Base Information

• Chemical Name: 4-(Trifluoroacetyl)-diphenyl ether
• CAS No.: 71151-89-8
• Molecular Formula: C14H9 F3 O2
• Molecular Weight: 266.219
• Mol file: 71151-89-8.mol

Synonyms:Aceticacid, trifluoro-, [1,1'-biphenyl]-4-yl ester (9CI); p-Trifluoroacetoxybiphenyl

Chemical Property of 4-(Trifluoroacetyl)-diphenyl ether

Chemical Property:

• PSA: 26.30000
• LogP: 3.82130

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Trifluoroacetyl)-diphenyl ether

There total 4 articles about 4-(Trifluoroacetyl)-diphenyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium 2,2,2-trifluoroacetate (2923-18-4) + potassium biphenyl-4-yltrifluoroborate → 1,1'-biphenyl-4-yl α,α,α-trifluoroacetate (71151-89-8)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 25 ℃; for 16h; Sealed tube;

DOI:10.1055/s-0035-1562529

Reference yield:

C14H9F3N2O2 → 1,1'-biphenyl-4-yl α,α,α-trifluoroacetate (71151-89-8)

Guidance literature:

In acetic anhydride; acetic acid; at 20 ℃; for 24h;

DOI:10.1021/ol026051d

Reference yield:

2,2,2-trifluoro-4'-phenylacetanilide (347-37-5) → 1,1'-biphenyl-4-yl α,α,α-trifluoroacetate (71151-89-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaNO₂ / acetic anhydride; acetic acid / 2 h / 0 °C

2: acetic anhydride; acetic acid / 24 h / 20 °C

With sodium nitrite; In acetic anhydride; acetic acid;

DOI:10.1021/ol026051d

upstream raw materials:

2,2,2-trifluoro-4'-phenylacetanilide

sodium 2,2,2-trifluoroacetate

Downstream raw materials:

benzoic acid

4-hydroxy-benzoic acid

4-Phenylphenol

Refernces

• 1、 Glatzhofer, Daniel T.,Roy, Raymond R.,Cossey, Kimberly N.. "Conversion of N-aromatic amides to O-aromatic esters". . p. 2349 - 2352. Retrieved 2007/10/03.