M-aMinoMethylbenzyl Methyl ether

Base Information

• Chemical Name: M-aMinoMethylbenzyl Methyl ether
• CAS No.: 148278-90-4
• Molecular Formula: C₉H₁₃NO
• Molecular Weight: 151.208
• Mol file: 148278-90-4.mol

Synonyms:1-{3-[(methyloxy)methyl]phenyl}methanamine

Chemical Property of M-aMinoMethylbenzyl Methyl ether

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

(3-(Methoxymethyl)phenyl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of M-aMinoMethylbenzyl Methyl ether

There total 7 articles about M-aMinoMethylbenzyl Methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(3-Cyanophenyl)methyl methyl ether (1515-86-2) → 1-{3-[(methyloxy)methyl]phenyl}methanamine (148278-90-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1135/cccc2010051

Reference yield:

3-(methoxymethyl)benzyl alcohol (522622-95-3) → 1-{3-[(methyloxy)methyl]phenyl}methanamine (148278-90-4)

Guidance literature:

With diphenyl phosphoryl azide;

Reference yield:

3-Methylbenzonitrile (620-22-4) → 1-{3-[(methyloxy)methyl]phenyl}methanamine (148278-90-4)

Guidance literature:

Multi-step reaction with 5 steps

1: chromium trioxide, acetic acid

2: water

3: sodium borohydride / ethanol

4: NaH / tetrahydrofuran

5: diborane / tetrahydrofuran

With chromium(VI) oxide; sodium tetrahydroborate; water; sodium hydride; acetic acid; diborane; In tetrahydrofuran; ethanol;

DOI:10.1002/oms.1210280203

upstream raw materials:

(3-Cyanophenyl)methyl methyl ether

3-Cyanobenzaldehyde

3-(hydroxymethyl)benzonitrile

3-Methylbenzonitrile

Downstream raw materials:

C₃₅H₄₆FN₃O₇

Refernces

• 1、 -. "SUBSTITUTED 2- AMIDOQUINAZOL-4-ONES AS MATRIX METALLOPROTEINASE-13 INHIBITORS". Paragraph 1897-1899. . Retrieved 2015/12/23.
• 2、 Nakata, Hisao,Kadoguchi, Kenji,Konishi, Hideyuki,Takeda, Naohito,Tatematsu, Akira. "Protonation Susceptibility and Fragmentation Capability of Functional Groups in Chemical Ionization Mass Spectrometry of Simple Bifunctional Compounds. Semi-quantitative Interpretation of Spectra.". . p. 67 - 70. Retrieved 2007/10/02.