4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine

Base Information

Chemical Name:4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine
CAS No.:186347-35-3
Molecular Formula:C₂₀H₂₈ClN₃O₂
Molecular Weight:377.914
Hs Code.:

Synonyms:4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine

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Chemical Property of 4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine

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Technology Process of 4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine

There total 4 articles about 4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 186347-33-1
4-(2-chlorophenyl)-piperidine-4-carbonitrile hydrochloride

: 83948-53-2
3-bromopropylamine tert-butylcarbamate

: 186347-35-3
4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 2856-63-5
2-Chlorophenylacetonitrile

: 186347-35-3
4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 60 °C

2: HCl / ethyl acetate

With hydrogenchloride; sodium hydride; In ethyl acetate; N,N-dimethyl-formamide; 1: spiroannulation reaction / 2: deprotection / 3: Alkylation;
DOI:10.1016/S0960-894X(00)00307-3

Reference yield:

: 186347-31-9
4-(2-chlorophenyl)-4-cyanopiperidine-1-carboxylic acid tert-butyl ester

: 186347-35-3
4-(2-Chlorophenyl)-4-cyano-N-(3-[N-{1,1-dimethylethoxycarbonyl}]amino)propylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethyl acetate

With hydrogenchloride; In ethyl acetate; 1: deprotection / 2: Alkylation;
DOI:10.1016/S0960-894X(00)00307-3