2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid

Base Information

Chemical Name:2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid
CAS No.:1429764-29-3
Molecular Formula:C₂₀H₁₆BrNO₆S₂
Molecular Weight:510.386
Hs Code.:

Synonyms:2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid

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Chemical Property of 2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid

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Technology Process of 2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid

There total 6 articles about 2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 518303-20-3
2-((4-(4-bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid

: 75-36-5
acetyl chloride

: 1429764-29-3
2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid

Guidance literature:: 2-((4-(4-bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid; With triethylamine; In tetrahydrofuran; at 0 ℃; for 0.0833333h;

acetyl chloride; In tetrahydrofuran; at 0 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 1429765-70-7
2-iodo-1-methoxy-4-nitronaphthalene

: 1429764-29-3
2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate; zinc(II) chloride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

1.2: 20 h / 60 °C / Inert atmosphere

2.1: iron; acetic acid / 1 h / 70 °C / Inert atmosphere

3.1: pyridine / dichloromethane / 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

With pyridine; boron tribromide; iron; caesium carbonate; acetic acid; triethylamine; zinc(II) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm500010b

Reference yield:

: 4900-63-4
1-methoxy-4-nitronaphthalene

: 1429764-29-3
2-((1-acetoxy-4-(4-bromophenylsulfonamido)naphthalen-2-yl)thio)acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide; trifluoroacetic acid / Reflux; Inert atmosphere

2.1: caesium carbonate; zinc(II) chloride / tetrahydrofuran / 0.33 h / 20 °C / Inert atmosphere

2.2: 20 h / 60 °C / Inert atmosphere

3.1: iron; acetic acid / 1 h / 70 °C / Inert atmosphere

4.1: pyridine / dichloromethane / 20 °C / Inert atmosphere

5.1: boron tribromide / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

With pyridine; N-iodo-succinimide; boron tribromide; iron; caesium carbonate; acetic acid; triethylamine; trifluoroacetic acid; zinc(II) chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm500010b