benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Base Information

Chemical Name:benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate
CAS No.:1609468-04-3
Molecular Formula:C₃₁H₃₉N₅O₄Si
Molecular Weight:573.767
Hs Code.:

Synonyms:benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

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Chemical Property of benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

There total 5 articles about benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609468-03-2
benzyl 3-(5-amino-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

: 75-36-5
acetyl chloride

: 1609468-04-3
benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16.5h;

Reference yield:

: 1609468-02-1
2-((4-((tert-butyldimethylsilyl)oxy)phenyl )(methoxy)methylene)malononitrile

: 1609468-04-3
benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / 16 h / Reflux

2: triethylamine / dichloromethane / 16.5 h / 0 - 20 °C

With triethylamine; In ethanol; dichloromethane;

Reference yield:

: 99-96-7
4-hydroxy-benzoic acid

: 1609468-04-3
benzyl 3-(5-acetamido-3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-4-cyano-1H-pyrazol-1-yl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

2.1: sodium hydride / tetrahydrofuran / 1 h / 0 °C

2.2: 1 h / -30 °C

2.3: 19 h / 0 - 20 °C / Reflux

3.1: triethylamine / ethanol / 16 h / Reflux

4.1: triethylamine / dichloromethane / 16.5 h / 0 - 20 °C

With 1H-imidazole; sodium hydride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;