5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Base Information

Chemical Name:5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS No.:191285-70-8
Molecular Formula:C₃₂H₃₁Cl₂N₃O₈
Molecular Weight:656.519
Hs Code.:

Synonyms:5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

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Chemical Property of 5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

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Technology Process of 5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

There total 6 articles about 5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 112641-19-7
Ethyl 4-(2-(2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethoxy)ethoxy)-3-oxobutanoate

: 2-cyanoethyl-2-(2,3-dichlorobenzylidene)-3-oxobutanoate

: 191285-70-8
5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: With ammonium formate; In ethanol; at 40 ℃; for 72h;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 191285-70-8
5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / DMF / 17 h / Heating

2: 90 percent / Jones reagent / acetone / 1 h

3: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

4: 4 h / Heating

5: 50 percent / ammonium formate / ethanol / 72 h / 40 °C

With pyridine; jones reagent; ammonium formate; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In ethanol; acetone;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 1074-82-4
potassium phtalimide

: 191285-70-8
5-(2-cyanoethyl)-3-ethyl-(+/-)-2-{[2-(2-phthalimidoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / DMF / 17 h / Heating

2: 90 percent / Jones reagent / acetone / 1 h

3: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

4: 4 h / Heating

5: 50 percent / ammonium formate / ethanol / 72 h / 40 °C

With pyridine; jones reagent; ammonium formate; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; In ethanol; acetone;
DOI:10.1016/S0968-0896(97)00024-2