2-oxo-cyclohexanecarboxylic acid p-toluidide

Base Information

• Chemical Name: 2-oxo-cyclohexanecarboxylic acid p-toluidide
• CAS No.: 126486-35-9
• Molecular Formula: C₁₄H₁₇NO₂
• Molecular Weight: 231.294
• Mol file: 126486-35-9.mol

Synonyms:2-oxo-cyclohexanecarboxylic acid p-toluidide

Chemical Property of 2-oxo-cyclohexanecarboxylic acid p-toluidide

Chemical Property:

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Technology Process of 2-oxo-cyclohexanecarboxylic acid p-toluidide

There total 1 articles about 2-oxo-cyclohexanecarboxylic acid p-toluidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

p-toluidine (106-49-0,12221-03-3) + ethyl 2-oxocyclohexane carboxylate (1655-07-8) → 2-oxo-cyclohexanecarboxylic acid p-toluidide (126486-35-9)

Guidance literature:

With dmap; In toluene; for 20h; Heating;

DOI:10.1055/s-1989-27383

Reference yield: 94.0%

2-oxo-cyclohexanecarboxylic acid p-toluidide (126486-35-9) + dibenzoyl peroxide (94-36-0) → C21H21NO4

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; CHF₃O₃S*C₁₀H₂₄N₂; In chloroform; at 20 ℃; enantioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol503592n

Reference yield: 80.0%

2-oxo-cyclohexanecarboxylic acid p-toluidide (126486-35-9) → C14H17NO3

Guidance literature:

With 2,2,2-Trifluoroacetophenone; dihydrogen peroxide; C₈H₂₀N₂*C₂HF₆NO₄S₂; In water; 1,2-dichloro-ethane; toluene; at 20 ℃; for 4h; enantioselective reaction;

DOI:10.1021/jacs.0c11787

upstream raw materials:

p-toluidine

ethyl 2-oxocyclohexane carboxylate

Refernces