4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 769961-49-1
• Molecular Formula: C₃₁H₃₄ClN₅O₆
• Molecular Weight: 608.094

Synonyms:4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

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Technology Process of 4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester

There total 2 articles about 4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(3,4-diamino-phenoxy)-pyridine-2-carboxylic acid methylamide (485841-49-4) + 4-(5-amino-2-chloro-phenoxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (1034491-93-4) + 1,1'-Thiocarbonyldiimidazole (6160-65-2) → 4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester (769961-49-1)

Guidance literature:

4-(5-amino-2-chloro-phenoxymethyl)-piperidine-1-carboxylic acid tert-butyl ester; 1,1'-Thiocarbonyldiimidazole; In dichloromethane; at 20 ℃; for 18h;

4-(3,4-diamino-phenoxy)-pyridine-2-carboxylic acid methylamide; In dichloromethane; for 16h;

With 1-(3-dimethyl-aminopropyl)-3-ethylcarbodiimide; In dichloromethane; at 20 ℃; for 3h; Further stages.;

DOI:10.1021/jm070034i

Reference yield:

→ 4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester (769961-49-1)

Guidance literature:

Reference yield:

4-{2-chloro-5-[5-(2-methylcarbamoyl-pyridin-4-yloxy)-benzoxazol-2-ylamino]-phenoxymethyl}-piperidine-1-carboxylic acid tert-butyl ester (769961-49-1) → 4-{2-[4-chloro-3-(piperidin-4-ylmethoxy)-phenylamino]-benzoxazol-5-yloxy}-pyridine-2-carboxylic acid methylamide

Guidance literature:

With trifluoroacetic acid; at 20 ℃; for 3h;

DOI:10.1021/jm070034i

upstream raw materials:

4-(3,4-diamino-phenoxy)-pyridine-2-carboxylic acid methylamide

4-(5-amino-2-chloro-phenoxymethyl)-piperidine-1-carboxylic acid tert-butyl ester

1,1'-Thiocarbonyldiimidazole

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