diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate

Base Information

• Chemical Name: diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate
• CAS No.: 219591-81-8
• Molecular Formula: C₃₀H₃₅F₂N₃O₈
• Molecular Weight: 603.62
• Mol file: 219591-81-8.mol

Synonyms:diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate

Chemical Property of diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate

There total 11 articles about diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

4-[bis-(2-fluoro-ethyl)-amino]-phenol (219592-00-4) + diprop-2-enyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate (180839-15-0) → diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate (219591-81-8)

Guidance literature:

With resin-Amberlyst 27 OH^-; In acetonitrile; for 20h;

DOI:10.1021/jm980425k

Reference yield:

2-(4-nitrobenzyloxy)tetrahydro-2H-pyran (18483-99-3) → diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate (219591-81-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 38 percent / ammonium formate / 10 percent Pd/C / ethanol / 1.5 h / 20 °C

2: Et₃N / toluene

3: 45 percent / aq. AcOH / tetrahydrofuran / 3.5 h / 45 °C

4: 48.6 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

5: 40 percent / resin-Amberlyst 27 OH^- / acetonitrile / 20 h

With resin-Amberlyst 27 OH^-; ammonium formate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene; acetonitrile;

DOI:10.1021/jm980425k

Reference yield:

4-nitrobenzyl chloride (619-73-8) → diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate (219591-81-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 1.5 h

2: 38 percent / ammonium formate / 10 percent Pd/C / ethanol / 1.5 h / 20 °C

3: Et₃N / toluene

4: 45 percent / aq. AcOH / tetrahydrofuran / 3.5 h / 45 °C

5: 48.6 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

6: 40 percent / resin-Amberlyst 27 OH^- / acetonitrile / 20 h

With resin-Amberlyst 27 OH^-; ammonium formate; pyridinium p-toluenesulfonate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; toluene; acetonitrile;

DOI:10.1021/jm980425k

upstream raw materials:

4-[bis-(2-fluoro-ethyl)-amino]-phenol

diprop-2-enyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate

4--O-benzylphenol

4--O-benzylphenol