18483-99-3

Basic information

• Product Name: 2H-Pyran, tetrahydro-2-[(4-nitrophenyl)methoxy]-
• CAS NO: 18483-99-3
• Molecular Formula: C12H15NO4
• Molecular Weight: 237.255
• Mol File: 18483-99-3.mol
• Article Data: 51

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, tetrahydro-2-[(4-nitrophenyl)methoxy]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, tetrahydro-2-[(4-nitrophenyl)methoxy]-(18483-99-3)
• EPA Substance Registry System: 2H-Pyran, tetrahydro-2-[(4-nitrophenyl)methoxy]-(18483-99-3)

Safety Data

• Hazardous Substances Data: 18483-99-3(Hazardous Substances Data)

Upstream product

• 619-90-9 4-nitrobenzyl acetate 
• 4457-41-4 4-nitrobenzyl benzoate 
• 110-87-2 3,4-dihydro-2H-pyran 
• 14856-73-6 4-nitrobenzyl trimethylsilyl ether 
• 49624-41-1 2-Fluor-tetrahydropyran 
• 619-73-8 4-nitrobenzyl chloride 
• 142-68-7 TETRAHYDROPYRANE 
• 100-51-6 benzyl alcohol 
• 69161-61-1 2-(prop-2-en-1-yloxy)oxane 

Downstream Products

• 619-78-3 1-dichloromethyl-4-nitrobenzene 
• 63289-53-2 4-nitrobenzyl isocyanate 
• 18484-05-4 4-aminobenzyl O-2'-tetrahydropyranyl ether 
• 219591-93-2 diprop-2-enyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbamoyl>-L-glutamate 
• 219591-81-8 diprop-2-enyl N-<(4-<<4-(bis<2-fluoroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate 
• 180839-04-7 diprop-2-enyl N-<(4-<amino>phenyl)carbamoyloxy>methyl>phenoxy)carbonyl>-L-glutamate 
• 180838-97-5 diprop-2-enyl N-<(4-<<4-(bis<2-chloroethyl>amino)phenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate 
• 180839-15-0 diprop-2-enyl N-<(4-<<4-nitrophenoxycarbonyloxy>methyl>phenyl)carbamoyl>-L-glutamate 
• 180839-11-6 diprop-2-enyl N-<(4-<<2'-tetrahydropyranyl>oxymethyl>phenyl)carbamoyl>-L-glutamate 
• 180839-13-8 diprop-2-enyl N-<(4-phenyl)carbamoyl>-L-glutamate 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 100-14-1 4-nitrobenzyl chloride 
• 3145-86-6 4-nitrobenzyl iodide 
• 17271-88-4 p-nitrobenzyl azide 

Relevant articles and documents

{[[K.18-Crown-6]Br3}n: A tribromide catalyst for the catalytic protection of amines and alcohols

{[K.18-Crown-6]Br3}n, a unique tribromide-type catalyst, was utilized for the N-boc protection of amines and trimethylsilylation (TMS) and tetrahydropyranylation (THP) of alcohols. The method is general for the preparation of N-boc derivatives of aliphatic (acyclic and cyclic) and aromatic, and primary and secondary amines and also various TMS-ethers and THP-ethers. The simple separation of the catalyst from the product is one of the many advantages of this method.

Highly selective tetrahydropyranylation/dehydropyranylation of alcohols and phenols using porous phenolsulfonic acid-formaldehyde resin catalyst under solvent-free condition

An efficient protocol for solvent-free chemoselective tetrahydropyranylation/depyranylation of alcohols and phenols is reported herein using mesoporous Phenolsulfonic Acid Formaldehyde Resins as a heterogeneous acid catalyst. The catalyst successfully performed chemoselective protection and deprotection reactions of a wide range of substrates ranging from primary to secondary and tertiary alcohols and also phenols. The reactions were carried out at ambient temperature under solvent-free condition (SolFC) which resulted in high yields within a very short time. FT-IR, TEM, SEM, EDS and TG-DSC analysis techniques were employed to characterize the synthesized polymeric catalyst. The chemoselective nature of our method was confirmed using 13C DEPT-135 NMR studies. The polymer catalyst was found to be recoverable even after 10th catalytic cycle without much depreciation in its activity. The heterogeneity of the catalyst was verified by hot filtration method. Good yield, energy and cost- effective method, solvent-free protocol, mild reaction conditions, no inert atmosphere, metal-free heterogeneous polymer catalyst and excellent recoverability of the catalyst are notable milestones of the reported protocol.

Direct Conversion of TMS-ethers to THP-ethers Catalyzed by {[K.18-Crown-6]Br3}n

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