(E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide

Base Information

Chemical Name:(E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide
CAS No.:1407499-65-3
Molecular Formula:C₂₆H₂₉N₃O₂
Molecular Weight:415.535
Hs Code.:

Synonyms:(E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide

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Chemical Property of (E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide

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Technology Process of (E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide

There total 6 articles about (E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 3408-21-7
1-benzoyl-2-isopropylhydrazine

: 1407499-74-4
(E)-3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acrylic acid

: 1407499-65-3
(E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1204-06-4,29953-71-7
trans-3-indole-acrylic acid

: 1407499-65-3
(E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 72 h / 60 °C

2: sodium hydride / N,N-dimethyl-formamide / 12 h / 80 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 12 h / 50 °C

4: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With water; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1002/bkcs.10123

Reference yield:

: 613-94-5
benzoic acid hydrazide

: 1407499-65-3
(E)-N'-isopropyl-N'-(3-(1-(3-methylbut-2-enyl)-1H-indol-3-yl)acryloyl)benzohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: hexane / 12 h / 65 °C

2: sodium cyanoborohydride; acetic acid / methanol / 18 h / 20 °C

3: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With sodium cyanoborohydride; acetic acid; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In methanol; hexane; N,N-dimethyl-formamide;
DOI:10.1002/bkcs.10123