tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

Base Information

Chemical Name:tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate
CAS No.:1571853-41-2
Molecular Formula:C₁₇H₂₅N₃O₂
Molecular Weight:303.404
Hs Code.:

Synonyms:tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

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Chemical Property of tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

Chemical Property:

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Technology Process of tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

There total 33 articles about tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (±)-tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

: 1571853-38-7
tert-butyl ((1S,5S)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

: 1571853-41-2
tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

Guidance literature:: With AD-H; In ethanol; Resolution of racemate;

Reference yield:

: 1187056-15-0
(±)-4-(5-methylcyclohexa-1,3-dienyl)-3-nitropyridine

: 1571853-41-2
tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

Guidance literature:: Multi-step reaction with 12 steps

1.1: N-Bromosuccinimide; water / tetrahydrofuran / 0.5 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h

2.2: 20 °C

3.1: ammonium hydroxide; trimethylphosphane / water; pyridine / 2 h / 20 °C

4.1: sodium hydrogencarbonate / 1,4-dioxane / 2 h / 20 °C

5.1: triethylamine / dichloromethane / 5 h / 0 °C

6.1: pyridine / 0.17 h / 110 °C / Microwave irradiation

7.1: triethylamine / dichloromethane / 0.67 h

8.1: lithium hydroxide / tetrahydrofuran / 20 h / 20 °C

9.1: pyridine / 5.08 h / 20 °C

10.1: palladium on activated charcoal; hydrogen / isopropyl alcohol / 16 h

11.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 100 °C

12.1: AD-H chiral column / ethanol; n-heptane / Resolution of racemate

With pyridine; ammonium hydroxide; N-Bromosuccinimide; palladium on activated charcoal; potassium tert-butylate; water; hydrogen; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: (±)-2-azido-6-methyl-4-(3-nitropyridin-4-yl)cyclohex-3-enol

: 1571853-41-2
tert-butyl ((1R,5R)-5-(3-aminopyridin-4-yl)-3-methylcyclohex-2-en-1-yl)carbamate

Guidance literature:: Multi-step reaction with 10 steps

1: ammonium hydroxide; trimethylphosphane / water; pyridine / 2 h / 20 °C

2: sodium hydrogencarbonate / 1,4-dioxane / 2 h / 20 °C

3: triethylamine / dichloromethane / 5 h / 0 °C

4: pyridine / 0.17 h / 110 °C / Microwave irradiation

5: triethylamine / dichloromethane / 0.67 h

6: lithium hydroxide / tetrahydrofuran / 20 h / 20 °C

7: pyridine / 5.08 h / 20 °C

8: palladium on activated charcoal; hydrogen / isopropyl alcohol / 16 h

9: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 3 h / 100 °C

10: AD-H chiral column / ethanol; n-heptane / Resolution of racemate

With pyridine; ammonium hydroxide; palladium on activated charcoal; hydrogen; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; lithium hydroxide; trimethylphosphane; In tetrahydrofuran; 1,4-dioxane; pyridine; ethanol; n-heptane; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;