2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester

Base Information

Chemical Name:2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester
CAS No.:146307-08-6
Molecular Formula:C₂₃H₂₂ClN₃O₅
Molecular Weight:455.898
Hs Code.:

Synonyms:2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester

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Chemical Property of 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester

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Technology Process of 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester

There total 3 articles about 2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 146307-07-5
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoyl chloride

: 146307-08-6
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester

Guidance literature:: With triethylamine; In dichloromethane; for 0.333333h; Ambient temperature;
DOI:10.3891/acta.chem.scand.46-1204

Reference yield:

: 146307-06-4
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoic acid

: 146307-08-6
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / PCl₅ / toluene / 24 h / 20 °C

2: 93 percent / Et₃N / CH₂Cl₂ / 0.33 h / Ambient temperature

With phosphorus pentachloride; triethylamine; In dichloromethane; toluene;
DOI:10.3891/acta.chem.scand.46-1204

Reference yield:

: 88045-96-9
4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzoic acid methyl ester

: 146307-08-6
2-<4-(5-chloro-2-oxo-1,2-dihydropyrimidin-1-ylmethoxymethyl)benzamido>-3-phenylpropionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / 20 nM ammoniumcarbonate buffer (pH 8.4) / 20 h / 37 °C / porcine liver esterase

2: 98 percent / PCl₅ / toluene / 24 h / 20 °C

3: 93 percent / Et₃N / CH₂Cl₂ / 0.33 h / Ambient temperature

With 20 nM ammoniumcarbonate buffer; phosphorus pentachloride; triethylamine; In dichloromethane; toluene;
DOI:10.3891/acta.chem.scand.46-1204