2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester

Base Information

Chemical Name:2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester
CAS No.:905459-63-4
Molecular Formula:C₃₇H₃₅ClFN₃O₄
Molecular Weight:640.154
Hs Code.:

2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1<i>H</i>-benzoimidazole-5-carboxylic acid methyl ester

Synonyms:2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester

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Chemical Property of 2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester

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Technology Process of 2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester

There total 6 articles about 2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 905459-64-5
2-[4-(4-acetylamino-4'-chlorobiphenyl-2-ylmethoxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester

: 74-88-4
methyl iodide

: 905459-63-4
2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester

Guidance literature:: 2-[4-(4-acetylamino-4'-chlorobiphenyl-2-ylmethoxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester; With sodium hydride; In N,N-dimethyl-formamide; for 0.25h; cooling;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm060269e

Reference yield:

: 480461-26-5
2-[4-(2-bromo-5-nitrobenzyloxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid methyl ester

: 905459-63-4
2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 1 h / Heating

2.1: tin(II) chloride dihydrate / ethanol; tetrahydrofuran / 1 h / Heating

3.1: Et₃N / CHCl₃ / 20 °C

4.1: NaH / dimethylformamide / 0.25 h / cooling

4.2: 52 percent / dimethylformamide / 20 °C

With sodium hydride; sodium hydrogencarbonate; triethylamine; tin(ll) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; N,N-dimethyl-formamide; 1.1: Suzuki coupling;
DOI:10.1021/jm060269e

Reference yield:

: 7149-70-4
2-bromo-5-nitrotoluene

: 905459-63-4
2-{4-[4-(acetyl-methyl-amino)-4'-chloro-biphenyl-2-ylmethoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-bromosuccinimide; 2,2'-azobisisobutyronitrile / CCl₄ / Heating

2.1: K₂CO₃ / dimethylformamide / 2.5 h / 80 °C

3.1: aq. NaHCO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 1 h / Heating

4.1: tin(II) chloride dihydrate / ethanol; tetrahydrofuran / 1 h / Heating

5.1: Et₃N / CHCl₃ / 20 °C

6.1: NaH / dimethylformamide / 0.25 h / cooling

6.2: 52 percent / dimethylformamide / 20 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hydride; sodium hydrogencarbonate; potassium carbonate; triethylamine; tin(ll) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; ethanol; chloroform; N,N-dimethyl-formamide; 3.1: Suzuki coupling;
DOI:10.1021/jm060269e