(S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:(S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester
CAS No.:162150-53-0
Molecular Formula:C₁₈H₂₈N₂O₄
Molecular Weight:336.431
Hs Code.:

Synonyms:(S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester

Suppliers and Price of (S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
N-Benzyl-N-[(R)-2-hydroxypropyl][(S)-2-(Boc-amino)propanamide]
1g
$ 937.00

Total 3 raw suppliers

Chemical Property of (S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester

Chemical Property:

Boiling Point:505.1±45.0 °C(Predicted)
Density:1.112±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

N-Benzyl-N-[(R)-2-hydroxypropyl][(S)-2-(Boc-amino)propanamide] ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester

There total 3 articles about (S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 15761-38-3
L-N-Boc-Ala

: 162240-94-0
(R)-1-<(Phenylmethyl)amino>-2-propanol

: 162150-53-0
(S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester

Guidance literature:: With 1,1'-carbonyldiimidazole; In dichloromethane; Ambient temperature;
DOI:10.1016/0957-4166(94)00341-8

Reference yield:

: 100-52-7
benzaldehyde

: 162150-53-0
(S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: magnesium sulfate / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

1.2: 74 h / 10 - 20 °C / Inert atmosphere

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 10 - 20 °C / Inert atmosphere

2.2: 16 h / 10 - 20 °C / Inert atmosphere

With magnesium sulfate; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane;

Reference yield:

: 100-52-7
benzaldehyde

: 162150-53-0
(S)-<2-<(2(R)-Hydroxypropyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) MgSO₄ 2.) NaBH₄ / 1.) THF, room temp., 3 h, 2.) EtOH, room temp., 72 h

2: 1.) 1,1'-carbonyldiimidazole / 1.) CH₂Cl₂, room temp., 1 h, 2.) CH₂Cl₂, room temp., 16 h

With sodium tetrahydroborate; magnesium sulfate; 1,1'-carbonyldiimidazole;
DOI:10.1021/jo00118a039