N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide

Base Information

Chemical Name:N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide
CAS No.:737824-52-1
Molecular Formula:C₂₁H₁₉N₃O₃S₂
Molecular Weight:425.532
Hs Code.:

Synonyms:N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide

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Chemical Property of N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide

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Technology Process of N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide

There total 9 articles about N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 737824-51-0
N-{4-formyl-5-[4-(methylthio)benzyl]-1,3-thiazol-2-yl}acetamide

: 2767-70-6
(p-nitrobenzyl)triphenylphosphonium bromide

: 737824-52-1
N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: With potassium tert-butylate; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 737824-50-9
ethyl 2-(acetylamino)-5-[4-(methylthio)benzyl]-1,3-thiazole-4-carboxylate

: 737824-52-1
N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / methanol; chloroform / 13 h / 20 °C / Inert atmosphere

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With manganese(IV) oxide; lithium aluminium tetrahydride; potassium tert-butylate; In tetrahydrofuran; methanol; chloroform; N,N-dimethyl-formamide; 3: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 874900-00-2
C₁₄H₁₆N₂O₂S₂

: 737824-52-1
N-{5-[4-(methylthio)benzyl]-4-[2-(4-nitrophenyl)vinyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: manganese(IV) oxide / methanol; chloroform / 13 h / 20 °C / Inert atmosphere

2: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With manganese(IV) oxide; potassium tert-butylate; In methanol; chloroform; N,N-dimethyl-formamide; 2: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048