4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

Base Information

• Chemical Name: 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine
• CAS No.: 1370001-96-9
• Molecular Formula: C₁₁H₁₇BN₂O₂
• Molecular Weight: 220.079
• Mol file: 1370001-96-9.mol

Synonyms:4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

Chemical Property of 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

Chemical Property:

• Boiling Point: 328.1±30.0 °C(Predicted)
• PKA: 1.66±0.16(Predicted)
• Density: 1.06±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine ^*data from reagent suppliers

Safty Information:

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Technology Process of 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine

There total 1 articles about 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-bromo-4-methylpyrimidine (1439-09-4) + bis(pinacol)diborane (73183-34-3) → 4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (1370001-96-9)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In dimethyl sulfoxide; at 90 ℃; Inert atmosphere;

Reference yield: 7.4%

4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (1370001-96-9) + 7-bromo-3-phenylbenzo[d]isoxazole (1428881-25-7) → 7-(4-methylpyrimidin-5-yl)-3-phenylbenzo[d]isoxazole (1428879-92-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 90 ℃; for 19h;

Reference yield:

4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine (1370001-96-9) + 3-bromo-N-(4-(chlorodifluoromethoxy)phenyl)-4-((3S,4S)-3,4-dihydroxypyrrolidin-1-yl)benzamide → N-(4-(chlorodifluoromethoxy)phenyl)-4-((3S,4S)-3,4-dihydroxypyrrolidin-1-yl)-3-(4-methylpyrimidin-5-yl)benzamide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In N,N-dimethyl-formamide; at 130 ℃; for 2h; Inert atmosphere; Sealed tube;

upstream raw materials:

5-bromo-4-methylpyrimidine

bis(pinacol)diborane

Downstream raw materials:

7-(4-methylpyrimidin-5-yl)-3-phenylbenzo[d]isoxazole

2-[5-(furo[3,2-c]pyridin-4-yloxy)-2-(4-methylpyrimidin-5-yl)phenyl]-2-methylpropanenitrile

2-[5-hydroxy-2-(4-methylpyrimidin-5-yl)phenyl]-2-methylpropanenitrile

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