3-<4-phenyl>-5-hexynoic acid

Base Information

Chemical Name:3-<4-phenyl>-5-hexynoic acid
CAS No.:144072-34-4
Molecular Formula:C₁₇H₂₁NO₄
Molecular Weight:303.358
Hs Code.:

3-<4-<N-(tertbutoxycarbonyl)amino>phenyl>-5-hexynoic acid

Synonyms:3-<4-phenyl>-5-hexynoic acid

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Chemical Property of 3-<4-phenyl>-5-hexynoic acid

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Technology Process of 3-<4-phenyl>-5-hexynoic acid

There total 11 articles about 3-<4-phenyl>-5-hexynoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 144072-40-2
ethyl 3-<4-phenyl>-5-hexynoate

: 144072-34-4
3-<4-phenyl>-5-hexynoic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 2h; Ambient temperature;
DOI:10.1021/jm00100a021

Reference yield:

: 623-04-1
4-aminobenzenemethanol

: 144072-34-4
3-<4-phenyl>-5-hexynoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / NaOH / dioxane; H₂O / 6 h / Ambient temperature

2: 85 percent / CrO₃, pyridine / 0.5 h / Ambient temperature

3: 1.) NaH / 1.) THF, 0 deg C, 1.5 h, 2.) THF, RT, 1 h

4: 1.) diisopropyl sulfide, CuI, 2.) TMSCl / 1.) ether, -78 deg C, 1 h, 2.) ether, -78 deg C, 1 h

5: 50 percent / Br₂ / diethyl ether / 1 h / 0 °C

6: 20percent aq. KOH / ethanol / 1 h / Ambient temperature

7: NaNH₂ / liquid ammonia / 1 h

With pyridine; chromium(VI) oxide; potassium hydroxide; sodium hydroxide; copper(l) iodide; chloro-trimethyl-silane; diisopropylsulfide; bromine; sodium hydride; sodium amide; In 1,4-dioxane; diethyl ether; ethanol; ammonia; water;
DOI:10.1021/jm00100a021

Reference yield:

: 144072-30-0
4-((tert-butoxycarbonyl)amino)benzaldehyde

: 144072-34-4
3-<4-phenyl>-5-hexynoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) NaH / 1.) THF, 0 deg C, 1.5 h, 2.) THF, RT, 1 h

2: 1.) diisopropyl sulfide, CuI, 2.) TMSCl / 1.) ether, -78 deg C, 1 h, 2.) ether, -78 deg C, 1 h

3: 50 percent / Br₂ / diethyl ether / 1 h / 0 °C

4: 20percent aq. KOH / ethanol / 1 h / Ambient temperature

5: NaNH₂ / liquid ammonia / 1 h

With potassium hydroxide; copper(l) iodide; chloro-trimethyl-silane; diisopropylsulfide; bromine; sodium hydride; sodium amide; In diethyl ether; ethanol; ammonia;
DOI:10.1021/jm00100a021