(S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate

Base Information

Chemical Name:(S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate
CAS No.:640281-37-4
Molecular Formula:C₂₅H₂₈BrN₃O₅
Molecular Weight:530.418
Hs Code.:

Synonyms:(S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate

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Chemical Property of (S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate

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Technology Process of (S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate

There total 6 articles about (S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1092806-31-9
Cbz-Val-(7-Bromo-Trp)-OH

: 77-76-9
2,2-dimethoxy-propane

: 640281-37-4
(S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate

Guidance literature:: With hydrogenchloride; In water; at 25 ℃; for 24h;

Reference yield: 76.0%

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: (+/-)-7-bromotryptophan methyl ester hydrochloride

: 640281-37-4
(S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate

Guidance literature:: With pyridine; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; at 0 ℃;
DOI:10.1002/anie.200352577

Reference yield:

: 72635-81-5
((benzyloxy)carbonyl)-L-valyl-L-serine

: 640281-37-4
(S,RS)-methyl 2-(2-benzyloxycarbonylamino-3-methylbutanoylamino)-3-(7-bromoindol-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic anhydride; acetic acid / 80 °C

2.1: hydrogenchloride / water / 24 h / 25 °C

2.2: 3 h

With hydrogenchloride; acetic anhydride; acetic acid; In water;