6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide

Base Information

Chemical Name:6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide
CAS No.:95250-13-8
Molecular Formula:C₂₅H₂₀Cl₂N₂O₆
Molecular Weight:515.35
Hs Code.:

Synonyms:6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide

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Chemical Property of 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide

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Technology Process of 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide

There total 7 articles about 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 95250-01-4
ethyl 6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxylate

: 95250-13-8
6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide

Guidance literature:: With ammonia; In ethanol; for 30h; Ambient temperature;
DOI:10.1021/jm50001a009

Reference yield:

: 13139-17-8
N-(Benzyloxycarbonyloxy)succinimide

: 95250-13-8
6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / aq. KHCO₃ / acetonitrile / 1.5 h

2: 92 percent / NH₃ (gas) / ethanol / 30 h / Ambient temperature

With ammonia; potassium hydrogencarbonate; In ethanol; acetonitrile;
DOI:10.1021/jm50001a009

Reference yield:

: 90246-55-2
6,7-Dichloro-2,3-dihydro-5-(p-hydroxybenzoyl)-benzofuran-2-carboxylic acid

: 95250-13-8
6,7-dichloro-2,3-dihydro-5-<3-<<(benzyloxycarbonyl)amino>methyl>-4-hydroxybenzoyl>-2-benzofurancarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / conc. H₂SO₄ / 24 h / Ambient temperature

2: 54 percent / conc. H₂SO₄ / 6 h / 10 - 15 °C

3: 58 percent / conc. aq. HCl / ethanol / 4 h / Heating

4: 92 percent / aq. KHCO₃ / acetonitrile / 1.5 h

5: 92 percent / NH₃ (gas) / ethanol / 30 h / Ambient temperature

With hydrogenchloride; sulfuric acid; ammonia; potassium hydrogencarbonate; In ethanol; acetonitrile;
DOI:10.1021/jm50001a009