N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide

Base Information

Chemical Name:N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide
CAS No.:1445992-68-6
Molecular Formula:C₂₂H₁₉N₃O₃
Molecular Weight:373.411
Hs Code.:

Synonyms:N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide

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Chemical Property of N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide

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Technology Process of N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide

There total 11 articles about N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1445993-91-8
N-(3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl)acetamide

: 1445992-68-6
N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide

Guidance literature:: With methanol; potassium carbonate; In water; at 110 ℃; for 0.5h; Microwave irradiation; Sealed tube;

Reference yield:

: 1445993-86-1
4-bromo-1-[(4-methylphenyl)sulfonyl]-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one

: 1445992-68-6
N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Inert atmosphere

1.2: 3 h / 20 °C

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; XPhos / 1 h / Inert atmosphere

2.2: 6 h / 80 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

4.1: potassium carbonate; water / methanol / 0.5 h / 110 °C / Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; potassium acetate; sodium hydride; sodium carbonate; potassium carbonate; XPhos; In methanol; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1159607-48-3
3-bromo-4-phenoxyaniline

: 1445992-68-6
N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxyphenyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 0.5 h / 100 °C / Microwave irradiation

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 0.5 h / 120 °C / Microwave irradiation; Inert atmosphere

3: potassium carbonate; water / methanol / 0.5 h / 110 °C / Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; potassium carbonate; In methanol; 1,2-dimethoxyethane; water;