1445993-86-1

Basic information

• Product Name: 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one
• Synonyms: 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one
• CAS NO: 1445993-86-1
• Molecular Formula: C14H11BrN2O3S
• Molecular Weight: 367.223
• Mol File: 1445993-86-1.mol
• Article Data: 26

Chemical Properties

• Density: 1.69±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one(1445993-86-1)
• EPA Substance Registry System: 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one(1445993-86-1)

Safety Data

• Hazardous Substances Data: 1445993-86-1(Hazardous Substances Data)

Usage

General Description

4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one is a chemical compound that belongs to the pyrrolopyridinone class. It is primarily used in pharmaceutical research and drug development. 4-bromo-1-tosyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one has a bromine atom and a tosyl group attached to a pyrrolopyridinone ring. Its molecular structure and properties make it a potentially useful component in the synthesis of novel pharmaceutical compounds with therapeutic applications. As such, it is of interest to medicinal chemists who are working on the development of new drugs, particularly in the areas of oncology and infectious diseases. Further research on this compound may reveal its potential for use in the medical field.

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 917918-81-1 2-(5-bromo-2-methoxy-3-nitropyridin-4-yl)-N,N-dimethylethenamine 
• 1258960-27-8 4-bromo-7-chloro-1-p-toluenesulfonyl-1H-pyrrolo[2,3-c]pyridine 
• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 425380-38-7 4-bromo-7-chloro-3a,7a-dihydro-1H-pyrrolo[2,3-c]pyridine 
• 1445993-85-0 4-bromo-7-methoxy-1-(4-methylbenzenesulfonyl)pyrrolo[2,3-c]pyridine 
• 425380-37-6 4-bromo-7-methoxy-1-hydro-pyrrolo[2,3-c]pyridine 
• 884495-14-1 5-bromo-2-methoxy-4-methyl-3-nitropyridine 
• 160590-36-3 2-methoxy-4-methyl-3-nitropyridine 
• 23056-39-5 2-chloro-3-nitro-4-methylpyridine 
• 152684-30-5 5-bromo-2-methoxy-3-nitropyridine 

Downstream Products

• 1446232-71-8 N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]propane-1-sulfonamide 
• 1446232-72-9 2,2,2-trifluoro-N-[3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)phenyl]ethanesulfonamide 
• 1445992-74-4 ethyl 3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxybenzoate 
• 1445992-76-6 3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxybenzoic acid 
• 1445992-84-6 3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-4-phenoxy-N-(tetrahydrofuran-2-ylmethyl)benzamide 
• 1446235-06-8 4-[2-(cyclopropylmethoxy)-5-fluorophenyl]-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 
• 1445993-88-3 4-(2-fluoro-5-nitrophenyl)-6-methyl-1-tosyl-1H-pyrrolo[2,3-c]-pyridin-7(6H)-one 
• 1445993-92-9 ethyl 4-fluoro-3-(6-methyl-7-oxo-1-tosyl-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzoate 
• 1445992-62-0 6-methyl-4-(2-phenoxyphenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]-pyridin-7-one 
• 1445994-30-8 4-(5-amino-2-(tetrahydro-2H-pyran-4-yloxy)phenyl)-6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one 
• 1445993-30-5 ethyl 4-(cyclopentylamino)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)benzoate 
• 1445992-63-1 6-methyl-4-(5-nitro-2-phenoxyphenyl)-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 
• 1445993-94-1 6-methyl-4-(5-nitro-2-(tetrahydro-2H-pyran-4-yloxy)phenyl)-1H-pyrrolo[2,3-c]pyridin-7(6H)-one 
• 1445992-64-2 4-(5-amino-2-phenoxyphenyl)-6-methyl-1,6-dihydro-7H-pyrrolo[2,3-c]pyridin-7-one 

Relevant articles and documents

Discovery of Dual TAF1-ATR Inhibitors and Ligand-Induced Structural Changes of the TAF1 Tandem Bromodomain

Bromodomains regulate chromatin remodeling and gene transcription through recognition of acetylated lysines on histones and other proteins. Bromodomain-containing protein TAF1, a subunit of general transcription factor TFIID, initiates preinitiation complex formation and cellular transcription. TAF1 serves as a cofactor for certain oncogenic transcription factors and is implicated in regulating the p53 tumor suppressor. Therefore, TAF1 is a potential target to develop small molecule therapeutics for diseases arising from dysregulated transcription, such as cancer. Here, we report the ATR kinase inhibitor AZD6738 (Ceralasertib) and analogues thereof as bona fide inhibitors of TAF1. Crystallographic and small-angle X-ray scattering studies established that newly identified and previously reported inhibitors stabilize distinct structural states of the TAF1 tandem bromodomain through “open-closed” transitions and dimerization. Combined with functional studies on p53 signaling in cancer cell lines, the data provide new insights into the feasibility and challenges of TAF1 inhibitors as chemical probes and therapeutics.

Compound with BRD4 inhibitory activity, preparation method and application thereof

The invention discloses a compound with BRD4 inhibitory activity, a preparation method and application thereof. The structure of the compound with the BRD4 inhibitory activity is shown as a formula I, and definitions of substituent groups are shown in the specification and claims. The compound provided by the invention has very high bromodomain protein inhibition activity, especially BRD4 targeted inhibition activity, and can be used for treating or/and preventing related diseases mediated by bromodomain protein.

COMPOUND FUNCTIONING AS BROMODOMAIN PROTEIN INHIBITOR, AND COMPOSITION

The invention relates to a bromodomain inhibitor. The invention also provides compositions and formulations comprising such compounds, and methods of using and preparing such compounds.