((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester

Base Information

Chemical Name:((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester
CAS No.:151477-88-2
Molecular Formula:C₄₄H₅₆N₂O₆
Molecular Weight:708.938
Hs Code.:

Synonyms:((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester

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Chemical Property of ((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester

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Technology Process of ((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester

There total 10 articles about ((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 156856-23-4
(2S,2'S)-<(1R,2R)-1,2-dibenzyloxy-ethan-diyl>bis(1-tert-butoxycarbonyl)-aziridine

: 6921-34-2
benzylmagnesium chloride

: 151477-88-2
((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: With copper(I) bromide dimethylsulfide complex; In diethyl ether; toluene; at -20 ℃; for 1h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 151477-88-2
((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N, DMAP / tetrahydrofuran

2: 61 percent / CuBr*Me₂S / diethyl ether; toluene / 1 h / -20 °C

With dmap; copper(I) bromide dimethylsulfide complex; triethylamine; In tetrahydrofuran; diethyl ether; toluene;

Reference yield:

: 36199-02-7
3,4-di-O-benzyl-D-mannitol

: 151477-88-2
((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: SOCl₂, Et₃N

2: RuCl₃, NaIO₄

3: LiN₃ / dimethylformamide / 2 h / 25 °C

4: aq. H₂SO₄ / tetrahydrofuran

5: Ph₃P / toluene / 2 h / 25 - 80 °C

6: Et₃N, DMAP / tetrahydrofuran

7: 61 percent / CuBr*Me₂S / diethyl ether; toluene / 1 h / -20 °C

With dmap; ruthenium trichloride; sodium periodate; thionyl chloride; lithium azide; copper(I) bromide dimethylsulfide complex; sulfuric acid; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; toluene;