156856-23-4

Upstream product

• 36199-02-7 3,4-di-O-benzyl-D-mannitol 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 151477-85-9 3,4-di-O-benzyl-1,2:5,6-di-O-sulfenyl-D-mannitol 
• 722539-36-8 3,4-di-O-benzyl-1,2:5,6-di-O-sulfinyl-D-mannitol 
• 111476-62-1 3,4-di-O-benzyl-1,2:5,6-di-O-isopropylidene-D-mannitol 
• 156764-21-5 3,4-di-O-benzyl-1,6-di-O-toluenesulfonyl-D-mannitol 
• 151477-86-0 1,6-diazido-1,6-dideoxy-3,4-di-O-benzyl-D-mannitol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 502699-56-1 (2S,2'S)-<(1R,2R)-1,2-dibenzyloxy-ethan-diyl>bis-aziridine 

Downstream Products

• 156764-24-8 (2S,3R,4R,5R)-2-Azidomethyl-3,4-bis-benzyloxy-5-(tert-butoxycarbonylamino-methyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 151477-88-2 ((1S,2R,3R,4S)-2,3-Bis-benzyloxy-4-tert-butoxycarbonylamino-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester 
• 184017-41-2 2-O-allyl-6-[(tert-butyloxycarbonyl)amino]-3,4-di-O-benzyl-1,5-[(tert-butyloxycarbonyl)imino]-1,5,6-trideoxy-D-mannitol 
• 184017-39-8 (2R,3R,4R,5S)-3,4-Bis-benzyloxy-2-(tert-butoxycarbonylamino-methyl)-5-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 172795-13-0 3,4-di-O-benzyl-6-[(tert-butyloxycarbonyl)amino]-2,5-[(1-oxycarbonyl)imino]-2,5,6-trideoxy-D-glucitol 
• 138328-94-6 ((1S,2R,3R,4S)-4-tert-Butoxycarbonylamino-2,3-dihydroxy-1-phenethyl-6-phenyl-hexyl)-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

New C2 symmetric bis-aziridines efficient synthesis of (2S,5S)-1,6-di(p-toluenesulfonyloxy)-2,5-hexanediol, and (2S,3E,5S)-1,6-di(p-toluenesulfonyloxy)-2,5-hexenediol

The regioselective tosylation and functionalization of (S,S)-1,2,5,6-hexanetetrol is reported. The reductive aminocyclization of conformationally flexible diazidodiols by PPh3 leads to C2 symmetric bis-aziridines and to substituted furans.

2,5-Disubstituted Pyrrolidines from D-Mannitol-Derived Bis-Aziridines

Concise synthesesof 3,4-dihydroxy-2,5-disubstituted pyrrolidines have been achieved starting from D-mannitol-derived flexible L-Ido bis-aziridines.Nucleophilic ring opening of the N-Boc and N-Cbz activated bis-aziridines by phenylthiolate and azide ions h

STEREOSELECTIVE SYNTHESIS OF DIAMINO DIOL DERIVATIVES WITH C2-AXIS OF SYMMETRY

An efficient and streocontrolled synthesis of C2-symmetric diamino diol derivatives (7) was achieved through selective opening of N-Boc bis-aziridine (6), prepared from D-mannitol via cyclic sulfate (4).