Technology Process of ethyl 3,5-dimethyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxylate
There total 4 articles about ethyl 3,5-dimethyl-1-(2-(3-(trifluoromethyl)benzyl)-1-benzothiophen-7-yl)-1H-pyrazole-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
pyridine;
copper(II) acetate hydrate;
at 50 ℃;
for 72h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: triethylamine / tetrahydrofuran / 0 - 20 °C
2: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran; water / 60 °C
3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / N,N-dimethyl-formamide / 85 °C
4: copper(II) acetate monohydrate; pyridine / 50 °C
With
pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; copper(II) acetate monohydrate; caesium carbonate; triethylamine;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2018.02.005
- Guidance literature:
-
Multi-step reaction with 3 steps
1: caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 / tetrahydrofuran; water / 60 °C
2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate / N,N-dimethyl-formamide / 85 °C
3: copper(II) acetate monohydrate; pyridine / 50 °C
With
pyridine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; copper(II) acetate monohydrate; caesium carbonate;
In
tetrahydrofuran; water; N,N-dimethyl-formamide;
1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2018.02.005
