2-(4-Chlorophenyl)-4-thiazolecarbonitrile

Base Information

Chemical Name:2-(4-Chlorophenyl)-4-thiazolecarbonitrile
CAS No.:17969-21-0
Molecular Formula:C₁₀H₅ClN₂S
Molecular Weight:220.682
Hs Code.:
DSSTox Substance ID:DTXSID601269182

Synonyms:DTXSID601269182;2-(4-Chlorophenyl)-4-thiazolecarbonitrile;17969-21-0

Suppliers and Price of 2-(4-Chlorophenyl)-4-thiazolecarbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(4-Chlorophenyl)-4-thiazolecarbonitrile

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:219.9861970
Heavy Atom Count:14
Complexity:242

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=NC(=CS2)C#N)Cl

Technology Process of 2-(4-Chlorophenyl)-4-thiazolecarbonitrile

There total 3 articles about 2-(4-Chlorophenyl)-4-thiazolecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 108735-90-6
2-(4-Chloro-phenyl)-thiazole-4-carbaldehyde oxime

: 17969-21-0
2-(4-chlorophenyl)thiazole-4-carbonitrile

Guidance literature:: With acetic anhydride; for 2h; Heating;

Reference yield:

: 21278-77-3
2-(4-chlorophenyl)thiazole-4-carbaldehyde

: 17969-21-0
2-(4-chlorophenyl)thiazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / NH₂OH / ethanol

2: 80 percent / (CH₃CO)2O / 2 h / Heating

With hydroxylamine; acetic anhydride; In ethanol;

Reference yield:

: 61786-00-3
ethyl 2-(4-chlorophenyl)thiazole-4-carboxylate

: 17969-21-0
2-(4-chlorophenyl)thiazole-4-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium aluminium tetrahydride / diethyl ether

1.2: 20 °C

2.1: iodine; ammonium hydroxide / tetrahydrofuran / 6 h / 20 °C

With ammonium hydroxide; lithium aluminium tetrahydride; iodine; In tetrahydrofuran; diethyl ether;
DOI:10.1002/jhet.3170