O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Base Information

Chemical Name:O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine
CAS No.:865710-39-0
Molecular Formula:C₂₉H₄₅ClN₄O₄Si₂
Molecular Weight:605.325
Hs Code.:

O<sup>6</sup>-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Synonyms:O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

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Technology Process of O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

There total 4 articles about O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 236427-57-9
O⁶-benzyl-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 865710-39-0
O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Guidance literature:: With chloro-trimethyl-silane; tert.-butylnitrite; In dichloromethane; at -10 ℃;
DOI:10.1021/jo050847j

Reference yield:

: 51549-35-0
3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

: 865710-39-0
O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃; DEAD / dioxane

2: 20 percent / tert-butylnitrite; chlorotrimethylsilane / CH₂Cl₂ / -10 °C

With chloro-trimethyl-silane; tert.-butylnitrite; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jo050847j

Reference yield:

: 961-07-9
2'-Deoxyguanosine

: 865710-39-0
O⁶-benzyl-2-chloro-3',5'-bis-O-(tert-butyldimethylsilyl)-2'-deoxyguanosine

Guidance literature:: Multi-step reaction with 3 steps

1: imidazole / dimethylformamide

2: PPh₃; DEAD / dioxane

3: 20 percent / tert-butylnitrite; chlorotrimethylsilane / CH₂Cl₂ / -10 °C

With 1H-imidazole; chloro-trimethyl-silane; tert.-butylnitrite; triphenylphosphine; diethylazodicarboxylate; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 2: Mitsunobu reaction;
DOI:10.1021/jo050847j