N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide

Base Information

• Chemical Name: N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide
• CAS No.: 697805-63-3
• Molecular Formula: C₁₇H₂₃N₃O₃
• Molecular Weight: 317.388

Synonyms:N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide

Chemical Property of N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide

Chemical Property:

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Technology Process of N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide

There total 1 articles about N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H29N3O5 (697805-62-2) → N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide (697805-63-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield: 76.0%

N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide (697805-63-3) + N-(4-{[(tert-butuoxycarbonyl)-amino]methyl}benzoyl)glycine (697806-14-7) → C32H41N5O7 (697805-64-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 0 ℃;

Reference yield: 76.0%

N-({(5S)-3-[4-(3-methylazetidin-3-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methyl)propanamide (697805-63-3) + 4-(4-amino-phenyl)-4-oxo-butyric acid (6945-94-4) → N-{[(5S)-3-(4-{1-[4-(4-aminophenyl)-4-oxobutanoyl]-3-methylazetidin-3-yl}phenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}propanamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 14h;

upstream raw materials:

C₂₅H₂₉N₃O₅

Downstream raw materials:

C₃₂H₄₁N₅O₇

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