6945-94-4

Usage

InChI:InChI=1/C10H11NO3/c11-8-3-1-7(2-4-8)9(12)5-6-10(13)14/h1-4H,5-6,11H2,(H,13,14)

Upstream product

• 103-84-4 Acetanilid 
• 108-30-5 succinic acid anhydride 
• 5473-15-4 4-(4-acetamidophenyl)-4-oxobutanoic acid 

Downstream Products

• 21282-90-6 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone 
• 52241-06-2 6-(4-aminophenyl)-2-methyl-4,5-dihydropyridazine-3(2H)-one 
• 63471-86-3 4-[4-(4-chloro-benzoylamino)-phenyl]-4-oxo-butyric acid 
• 52240-85-4 4-(4-amino-phenyl)-4-oxo-butyric acid,methyl ester 
• 1221170-26-8 6-{4-[2-(1-N-methylcarbamoyl-1-{1-(N-methylimino)ethyl}-methylidene)-hydrazino]phenyl}-4,5-dihydro-3(2H)-pyridazinone 
• 1221170-27-9 C₂₀H₂₈N₆O₂ 
• 1221170-31-5 C₃₀H₃₂N₆O₂ 
• 1221170-28-0 C₁₈H₂₃N₅O₃ 
• 1221170-29-1 C₂₀H₂₅N₅O₃ 
• 1221170-30-4 C₁₇H₂₁N₅O₃ 
• 1221170-32-6 C₁₅H₁₈N₆O₃ 
• 1221170-33-7 C₁₇H₂₂N₆O₃ 
• 1221170-34-8 C₁₉H₂₆N₆O₃ 
• 1221170-35-9 C₂₅H₃₄N₆O₃ 

Relevant academic research and scientific papers

Design, synthesis and molecular modeling of phenyl dihydropyridazinone derivatives as B-Raf inhibitors with anticancer activity

Three new series of phenyl dihydropyridazinone derivatives 4b–8i have been designed, synthesized and evaluated for their anticancer activity against different cancer cell lines. Nine compounds showed strong inhibitory activity, among which compound 8b exh

Synthesis under moderate pressure of 3-imidazo[1,2-a]pyridinylidene pyrrol-2-ones

Conversion of 3-imidazo[1,2-a]pyridinylidene furan-2-ones into their pyrrol-2-one analogues was achieved efficiently with high yields, using a solution of ammonium hydroxide under moderate pressure conditions. A NMR study showed that the compounds are mainly isolated as E isomers.

Synthesis of new 4,5-3(2H)pyridazinone derivatives and their cardiotonic, hypotensive, and platelet aggregation inhibition activities

4,5-dihydro-3(2H)pyridazinones such as CI-914, CI-930 and pimobendan along with tetrahydropyridopyridazine (endralazine) and perhydropyridazinodiazepine (cilazopril) have been used as potent positive inotropes, antihypertensives as well as platelet aggreg

Synthesis and bioactivity of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

A series of 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives was prepared and examined for cardiotonic activity. The structures of these new pyridazinone derivatives were confirmed by IR, 1H-NMR and mass spectrum. The cardiotonic activities of these compounds were studied on isolated perfused toad heart and compared with the activity of levosimendan (CAS 141505-33-1). Compound 5a emerged as the most interesting compound in this series with potential cardiotonic activity. ECV Editio Cantor Verlag.

N-(4-(PIPERAZIN-1-YL)-PHENYL-2-OXAZOLIDINONE-5-CARBOXAMIDE DERIVATES AND RELATED COMPOUNDS AS ANTIBACTERIAL AGENTS

The present invention provides antibacterial agents having the formula I described herein. or-pharmaceutically acceptable salts thereof wherein: A is a structure i, ii, iii, or iv,W is N(H)C(X)-R,. Het, or -Y HET, in which the Hot or Y HET is option

Benzene butyric acids and their derivatives as inhibitors of matrix metalloproteinases

Benzene butyric acid compounds and derivatives are described as well as methods for the preparation and pharmaceutical compositions of same, which are useful as inhibitors of matrix metalloproteinases, particularly gelatinase A, collagenase-3, and stromel

6-Aryl-4,5-dihydro-3(2H)-pyridazinones. A new class of compounds with platelet aggregation inhibiting and hypotensive activities

This paper reports on the synthesis and pharmacological activity of 6-aryl-4,5-dihydro-3(2H)-pyridazinone derivatives. The compounds exhibit an aggregation inhibiting action on human platelets in vitro and on rat platelets under ex vivo conditions, as wel