((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate

Base Information

Chemical Name:((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate
CAS No.:1254160-16-1
Molecular Formula:C₁₆H₂₂N₆O₆
Molecular Weight:394.387
Hs Code.:

Synonyms:((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate

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Chemical Property of ((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate

Chemical Property:

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Technology Process of ((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate

There total 7 articles about ((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3369-66-2
((3aR,4R,6R,6aR)-6-(6-(cyclohexylamino)-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol

: 1254160-16-1
((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate

Guidance literature:: ((3aR,4R,6R,6aR)-6-(6-(cyclohexylamino)-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methanol; With nitric acid; acetic anhydride; at -25 - 0 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate; for 0.0833333h; Cooling with iceacetone-dry ice;

Reference yield:

: C₁₉H₂₆N₆O₆

: 1254160-16-1
((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate

Guidance literature:: With water; trifluoroacetic acid; at 20 ℃; for 0.5h;

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 1254160-16-1
((2R,3S,4R,5R)-5-(6-(cyclohexylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl nitrate

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 6 h / Reflux

2: (1S)-10-camphorsulfonic acid / acetone / 18 h / 20 °C

3: nitric acid; acetic anhydride / water / 2 h / -5 - 0 °C

4: trifluoroacetic acid; water / 0.5 h / 20 °C

With (1S)-10-camphorsulfonic acid; water; nitric acid; acetic anhydride; trifluoroacetic acid; In ethanol; water; acetone;