1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane

Base Information

Chemical Name:1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane
CAS No.:866414-16-6
Molecular Formula:C₃₆H₅₀Cl₂N₄O₆
Molecular Weight:705.722
Hs Code.:

Synonyms:1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane

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Chemical Property of 1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane

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Technology Process of 1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane

There total 2 articles about 1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 63024-77-1
3-(Chloromethyl)benzoyl chloride

: 170161-29-2
di-tert-butyl 1,4,8,11-tetraazacyclotetradecane-1,8-dicarboxylate

: 866414-16-6
1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: With triethylamine; at 20 ℃; for 1h;
DOI:10.1039/b508076b

Reference yield:

: 866414-15-5
1,8-dibenzyl-4,11-bis(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

: 866414-16-6
1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / H₂ / Pd/C / acetic acid; methanol / 1 h

2: 85 percent / triethylamine / 1 h / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; acetic acid;
DOI:10.1039/b508076b