170161-29-2

Upstream product

• 295-37-4 1,4,8,11-Tetraazacyclotetradecane 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 414858-13-2 1,8-bis(tert-butoxycarbonyl)-4,11-bis[4-(chloromethyl)benzoyl]-1,4,8,11-tetraazacyclotetradecane 
• 866414-16-6 1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-chloromethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane 
• 866414-17-7 1,8-di(tert-butyloxycarbonyl)-4,11-bis(3'-iodomethylbenzoyl)-1,4,8,11-tetraazacyclotetradecane 
• 890706-84-0 4,11-bis-{4-[13-(2,2,2-trichloro-ethoxycarbonyl)-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl]-benzoyl}-1,4,8,11tetraaza-cyclotetradecane-1,8-dicarboxylic acid di-tert-butyl ester 
• 890706-77-1 16-(4-{[4,11-bis(tert-butoxycarbonyl)-8-{4-[(13-tert-butoxycarbonyl-1,9-dithia-5,13-diazacyclohexadecan-5-yl)methyl]benzoyl}-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-1,4,7,10,13-pentaoxa-16-azacyclooctadecane 
• 890706-73-7 5-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-13-(2,2,2-trichloroethoxycarbonyl)-1,9-dithia-5,13-diazacyclohexadecane 
• 890706-76-0 5-tert-butoxycarbonyl-13-[4-({4,11-bis(tert-butoxycarbonyl)-8-[4-(chloromethyl)benzoyl]-1,4,8,11-tetraazacyclotetradecan-1-yl}carbonyl)benzyl]-1,9-dithia-5,13-diazacyclohexadecane 
• 890706-72-6 5-tert-butoxycarbonyl-13-(4-{[4,11-bis(tert-butoxycarbonyl)-8-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-1,9-dithia-5,13-diazacyclohexadecane 
• 890706-74-8 5-tert-butoxycarbonyl-13-(4-{[4,11-bis(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-1,9-dithia-5,13-diazacyclohexadecane 
• 890706-75-9 5-(4-{[4,11-bis(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecan-1-yl]carbonyl}benzyl)-1,9-dithia-5,13-diazacyclohexadecane 
• 890706-71-5 1,8-bis(tert-butoxycarbonyl)-4-[4-(chloromethyl)benzoyl]-11-(2,2,2-trichloroethoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane 

Relevant academic research and scientific papers

Syntheses of new unsymmetrical bispolyazamacrocycles

We report the synthesis of an original unsymmetrical bismacrocycle bearing a carboxylic side-arm. Two different synthetic pathways were investigated, both involving a Schotten-Baumann like reaction. The first route allowed us to obtain a mixture of compounds whilst the second one was direct and non-ambiguous.

New bicyclam-AZT conjugates: Design, synthesis, anti-HIV evaluation, and their interaction with CXCR-4 coreceptor

We report the synthesis of mono- and bis-tetraazamacrocycle-AZT conjugates. All new compounds were screened for their ability to inhibit HIV- 1 replication in MT4 cell line and were compared to AZT alone. It appears that N-protected covalent prodrugs are

Characterization and application of a new diprotected cyclam: A novel two-step synthesis of linked tetraazamacrocycles

The synthesis and separation of the 1,8-di-(tertbutyloxycarbonyl) cyclam (1,8-diboc cyclam) among other isomers allow the facile obtention of singly or doubly linked, and bridged tetraazamacrocycles within a two-step synthesis in a very convenient way. This strategy can be applied to a large scale preparation of several types of dioxygen carriers or activators.