Technology Process of 7-decyl-3,2',3',4',6'-pentamethoxyflavone
There total 6 articles about 7-decyl-3,2',3',4',6'-pentamethoxyflavone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1139/v11-087
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 1.08 h / -78 - 20 °C / Inert atmosphere
1.3: 20 °C / Inert atmosphere
2.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
trimethylsilyl trifluoromethanesulfonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1139/v11-087
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / Inert atmosphere
2.1: water; potassium hydroxide / tetrahydrofuran / Inert atmosphere
3.1: potassium carbonate / acetone / Inert atmosphere
4.1: n-butyllithium / tetrahydrofuran / -78 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: thionyl chloride / 2 h / Inert atmosphere; Reflux
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
6.2: 1.08 h / -78 - 20 °C / Inert atmosphere
6.3: 20 °C / Inert atmosphere
7.1: trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C / Inert atmosphere
With
n-butyllithium; thionyl chloride; trimethylsilyl trifluoromethanesulfonate; water; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; potassium hydroxide; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; acetone;
1.1: Baeyer-Villiger oxidation;
DOI:10.1139/v11-087
