Technology Process of N-(2-(3-(tert-butyl)-5-isopropylphenyl)-2-methylpropyl)aniline
There total 3 articles about N-(2-(3-(tert-butyl)-5-isopropylphenyl)-2-methylpropyl)aniline which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazolium tetrafluoroborate; sodium t-butanolate;
In
toluene;
at 110 ℃;
for 4h;
Inert atmosphere;
DOI:10.1002/anie.201102880
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2′-(dicyclohexylphophanyl)-N2,N2,N6,N6-tetramethyl[1,1′-biphenyl]-2,6-diamine; palladium diacetate / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2: trimethyl phosphite; bromine / 14 h / 70 °C / Inert atmosphere
3: tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazolium tetrafluoroborate; sodium t-butanolate / toluene / 4 h / 110 °C / Inert atmosphere
With
trimethyl phosphite; tris-(dibenzylideneacetone)dipalladium(0); 2′-(dicyclohexylphophanyl)-N2,N2,N6,N6-tetramethyl[1,1′-biphenyl]-2,6-diamine; 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazolium tetrafluoroborate; bromine; palladium diacetate; sodium t-butanolate;
In
tetrahydrofuran; toluene;
DOI:10.1002/anie.201102880
- Guidance literature:
-
Multi-step reaction with 2 steps
1: trimethyl phosphite; bromine / 14 h / 70 °C / Inert atmosphere
2: tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazolium tetrafluoroborate; sodium t-butanolate / toluene / 4 h / 110 °C / Inert atmosphere
With
trimethyl phosphite; tris-(dibenzylideneacetone)dipalladium(0); 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazolium tetrafluoroborate; bromine; sodium t-butanolate;
In
toluene;
DOI:10.1002/anie.201102880