N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester

Base Information

Chemical Name:N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester
CAS No.:126823-67-4
Molecular Formula:C₃₂H₃₆N₂O₈
Molecular Weight:576.646
Hs Code.:

Synonyms:N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester

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Chemical Property of N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester

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Technology Process of N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester

There total 4 articles about N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 2419-54-7
N-(benzyloxycarbonyl)-β-benzyl-L-aspartic acid p-nitrophenyl ester

: 126823-65-2
D,L-2-furylglycine 2,5-dimethylcyclopentyl ester

: 126823-67-4
N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester

Guidance literature:: In tetrahydrofuran; 1.) 0 deg C, 1 h, 2.) RT, overnight;
DOI:10.1021/jm00168a022

Reference yield:

: 17119-54-9,64757-64-8
DL-2-amino-2-(furan-2-yl)acetic acid

: 126823-67-4
N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / Na₂CO₃ / H₂O / 1.5 h

2: 84 percent / dicyclohexylcarbodiimide (DCC), 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂; tetrahydrofuran / 1.) -65 deg C, 20 min, 2.) from -65 deg C to -23 deg C, 3 h

3: 100 percent / hydrazine hydrate / ethanol / 2.5 h / Heating

4: 83 percent / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, overnight

With dmap; sodium carbonate; hydrazine hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm00168a022

Reference yield:

: 112395-47-8
N-phthaloyl-D,L-2-furylglycine

: 126823-67-4
N-(benzyloxycarbonyl)-β-benzyl-L-aspartyl-D,L-2-furylglycine 2,5-dimethylcyclopentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / dicyclohexylcarbodiimide (DCC), 4-(dimethylamino)pyridine (DMAP) / CH₂Cl₂; tetrahydrofuran / 1.) -65 deg C, 20 min, 2.) from -65 deg C to -23 deg C, 3 h

2: 100 percent / hydrazine hydrate / ethanol / 2.5 h / Heating

3: 83 percent / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) RT, overnight

With dmap; hydrazine hydrate; dicyclohexyl-carbodiimide; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00168a022