((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

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Chemical Name:((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane
CAS No.:137792-85-9
Molecular Formula:C₂₁H₃₄O₅Si
Molecular Weight:394.583
Hs Code.:

Synonyms:((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

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Chemical Property of ((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

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Technology Process of ((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

There total 6 articles about ((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 137792-62-2
4-O-benzyl-6-O-tert-butyldimethylsilyl-D-(-)-glucal

: 107-30-2
chloromethyl methyl ether

: 137792-85-9
((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 11h; Ambient temperature;
DOI:10.1021/jo00028a033

Reference yield:

: 58871-09-3
6-O-tert-butyldimethylsilyl-D-glucal

: 137792-85-9
((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1: 9.8 g / pyridine / 0.33 h / -5 °C

2: 1) KH, 2) tetra-n-butylammonium iodide / 1) THF, 0 deg C, 15 min, 2) THF, rt, 6 h

3: 96 percent / diisopropylethylamine / CH₂Cl₂ / 11 h / Ambient temperature

With pyridine; tetra-(n-butyl)ammonium iodide; potassium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00028a033

Reference yield:

: 100-39-0
benzyl bromide

: 137792-85-9
((2R,3S,4R)-3-Benzyloxy-4-methoxymethoxy-3,4-dihydro-2H-pyran-2-ylmethoxy)-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 1) KH, 2) tetra-n-butylammonium iodide / 1) THF, 0 deg C, 15 min, 2) THF, rt, 6 h

2: 96 percent / diisopropylethylamine / CH₂Cl₂ / 11 h / Ambient temperature

With tetra-(n-butyl)ammonium iodide; potassium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00028a033