N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide
CAS No.:540744-14-7
Molecular Formula:C₁₉H₁₈N₂O₄S
Molecular Weight:370.429
Hs Code.:

Synonyms:N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide

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Chemical Property of N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide

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Technology Process of N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide

There total 3 articles about N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 540744-13-6
tert-butyl [(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)but-2-enyl][(4-methylphenyl)sulfonyl]carbamate

: 540744-14-7
N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1002/hlca.200390046

Reference yield:

: 18303-04-3
N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide

: 540744-14-7
N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / Cs₂CO₃ / dimethylformamide / 16 h / 20 °C

2: 93 percent / dimethylformamide / 12 h / 50 °C

3: 100 percent / CF₃COOH / CH₂Cl₂ / 4 h / 20 °C

With trifluoroacetic acid; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390046

Reference yield:

: 335004-44-9
N-[(E)-4-bromo-2-butenyl]-N-(tert-butyloxycarbonyl)-(4-methylphenyl)sulfonamide

: 540744-14-7
N-[(2E)-4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-but-2-enyl]-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / dimethylformamide / 12 h / 50 °C

2: 100 percent / CF₃COOH / CH₂Cl₂ / 4 h / 20 °C

With trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.200390046