1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol

Base Information

Chemical Name:1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol
CAS No.:77948-71-1
Molecular Formula:C₂₁H₂₁F₃N₂O₃
Molecular Weight:406.405
Hs Code.:

1-(1,4-benzodioxin-2-yl)-2-<N<sup>4</sup>-<3-(trifluoromethyl)phenyl>piperazino>ethanol

Synonyms:1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol

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Chemical Property of 1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol

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Technology Process of 1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol

There total 3 articles about 1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 77948-61-9
1-(1,4-benzodioxin-2-yl)-2-chloroethanol

: 15532-75-9
1-(3-Trifluoromethylphenyl)piperazine

: 77948-71-1
1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol

Guidance literature:: In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; at 85 ℃; for 40h;
DOI:10.1021/jm00140a015

Reference yield:

: 65456-19-1
ethyl 2,3-dibromo-2,3-dihydro-1,4-benzodioxin-2-carboxylate

: 77948-71-1
1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol

Guidance literature:: Multi-step reaction with 6 steps

1: sodium iodide / acetone / 1.5 h / Ambient temperature

2: 93 percent / 8percent NaOH / 1 h / 95 °C

3: 100 percent / thionyl chloride / benzene / 6 h / Heating

4: 2.) HCl / 1.) ether, a) -20 to -10 deg C, 30 min, b) RT, 14 h, 2.) ether, 2h

5: 100 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

6: 42 percent / hexamethylphosphoric acid triamide; tetrahydrofuran / 40 h / 85 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; sodium iodide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; acetone; benzene;
DOI:10.1021/jm00140a015

Reference yield:

: 67471-01-6
1,4-benzodioxin-2-carboxylic acid

: 77948-71-1
1-(1,4-benzodioxin-2-yl)-2-4-<3-(trifluoromethyl)phenyl>piperazino>ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / thionyl chloride / benzene / 6 h / Heating

2: 2.) HCl / 1.) ether, a) -20 to -10 deg C, 30 min, b) RT, 14 h, 2.) ether, 2h

3: 100 percent / LiAlH₄ / diethyl ether / 1 h / 20 °C

4: 42 percent / hexamethylphosphoric acid triamide; tetrahydrofuran / 40 h / 85 °C

With hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; benzene;
DOI:10.1021/jm00140a015