2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid

Base Information

Chemical Name:2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid
CAS No.:1427406-16-3
Molecular Formula:C₂₁H₁₆F₃NO₄
Molecular Weight:403.358
Hs Code.:

Synonyms:2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid

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Chemical Property of 2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid

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Technology Process of 2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid

There total 10 articles about 2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1427407-31-5
C₂₃H₂₀F₃NO₄

: 1427406-16-3
2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

: 1427407-27-9
methyl 3-(3-fluorophenyl)-5-methoxy-benzoate

: 1427406-16-3
2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

3.1: tetrahydrofuran / 2 h / 0 - 20 °C

4.1: borane-THF / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere; Reflux

5.1: caesium carbonate / N,N-dimethyl-formamide / 1 h

5.2: 1 h

6.1: aluminum (III) chloride; ethanethiol / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

7.1: sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

With aluminum (III) chloride; borane-THF; oxalyl dichloride; water; caesium carbonate; N,N-dimethyl-formamide; ethanethiol; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 140472-69-1
3-bromo-5-hydroxy-benzoic acid

: 1427406-16-3
2-[2,4-difluoro-3-[[3-(3-fluorophenyl)-5-hydroxyphenyl]methylamino]phenoxy]acetic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 20 °C

2.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; methanol / 4 h / 70 °C / Inert atmosphere

3.1: potassium hydroxide; water / tetrahydrofuran / 2 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

5.1: tetrahydrofuran / 2 h / 0 - 20 °C

6.1: borane-THF / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere; Reflux

7.1: caesium carbonate / N,N-dimethyl-formamide / 1 h

7.2: 1 h

8.1: aluminum (III) chloride; ethanethiol / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

9.1: sodium hydroxide / tetrahydrofuran / 3 h / 0 - 20 °C

With aluminum (III) chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; borane-THF; oxalyl dichloride; water; potassium carbonate; caesium carbonate; N,N-dimethyl-formamide; ethanethiol; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;