Technology Process of diphenylphosphoryl-2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranoside
There total 13 articles about diphenylphosphoryl-2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranoside which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,4,6-tri-O-acetyl-3-O-carbamoyl-α-D-mannopyranoside;
With
n-butyllithium;
In
tetrahydrofuran; cyclohexane;
at -78 ℃;
for 0.333333h;
Molecular sieve;
Inert atmosphere;
chlorophosphoric acid diphenyl ester;
In
tetrahydrofuran; cyclohexane;
for 1h;
Inert atmosphere;
- Guidance literature:
-
With
dmap; triethylamine;
In
dichloromethane;
at 0 ℃;
for 1.5h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / H2 / 10percent Pd(OH)2/C / methanol / 10 h / 25 °C / 760 Torr
2: 86 percent / pyridine, DMAP / 2 h / 40 °C
3: 88 percent / 10percent NH3/THF / CH2Cl2 / 1.5 h / 25 °C
4: 78 percent / benzylamine / tetrahydrofuran / 24 h / 25 °C
5: 1.) BuLi / 1.) THF, hexane, -78 deg C, 10 min, 2.) THF, hexane, -78 deg C, 10 min
With
tetrahydrofuran; pyridine; dmap; n-butyllithium; ammonia; hydrogen; benzylamine;
palladium dihydroxide;
In
tetrahydrofuran; methanol; dichloromethane;
