1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate

Base Information

• Chemical Name: 1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate
• CAS No.: 86905-85-3
• Molecular Formula: C₁₈H₂₂O₃
• Molecular Weight: 286.371
• Mol file: 86905-85-3.mol

Synonyms:1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate

Chemical Property of 1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate

There total 2 articles about 1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trimethyl-3,5,5 cyclohexene-3 ol-1 (19020-56-5) → 1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate (86905-85-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 63 percent / pyridine / benzene / 1) 10-15 deg C (addition), 2) reflux, 2 h, 3) r.t., 1 h

2: 1) Zn dust, phosphorous oxychloride, 2) Zn dust, NH₄Cl / 1) ether, 3 h (addition), 10 h (reflux), 2) methanol, reflux, 4 h

With pyridine; ammonium chloride; zinc; trichlorophosphate; In benzene;

DOI:10.1016/S0040-4020(01)91870-8

Reference yield:

3,5,5-trimethylcyclohex-3-en-1-yl benzoate (86905-75-1) + trifluoroacetyl chloride (76-02-8) → 1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate (86905-85-3) + 1,5,5-trimethylbicyclo<4.2.0>octan-8-on-3-yl benzoate (86905-84-2)

Guidance literature:

With ammonium chloride; zinc; trichlorophosphate; Yield given. Multistep reaction. Yields of byproduct given; 1) ether, 3 h (addition), 10 h (reflux), 2) methanol, reflux, 4 h;

DOI:10.1016/S0040-4020(01)91870-8

Reference yield: 90.0%

1,5,5-trimethylbicyclo<4.2.0>octan-7-on-3-yl benzoate (86905-85-3) → lactone of cis-2-hydroxy-4-benzyloxy-2,6,6-trimethyl-1-acetic acid (86905-88-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 ℃; for 24h;

DOI:10.1016/S0040-4020(01)91870-8

upstream raw materials:

3,5,5-trimethylcyclohex-3-en-1-yl benzoate

trifluoroacetyl chloride

trimethyl-3,5,5 cyclohexene-3 ol-1

Downstream raw materials:

lactone of cis-2-hydroxy-4-benzyloxy-2,6,6-trimethyl-1-acetic acid